Fluciclovine F 18 Intravenous Injection (Axumin)- FDA

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S90750 Editor who approved publication: Professor A. M KannanPriyanka Sinha, Anjuman Shekhawat, Digish K Sharma Electrochemical Research Laboratory, Department of Chemistry, University of Rajasthan, Jaipur, India Abstract: The electrochemical reduction behavior of selegiline was investigated by cyclic voltammetry using glassy carbon electrode and validated by square wave cathodic adsorptive stripping voltammetry.

The reduction process is irreversible and partial diffusion controlled. Various retinol roche posay and Fluciclovine F 18 Intravenous Injection (Axumin)- FDA parameters affecting the electroanalytical response for the determination of selegiline were investigated and optimized.

Under optimized conditions, the adsorptive stripping peak current is found to be linear over the concentration range of 3. Selegiline is an irreversible and relatively selective inhibitor of Fluciclovine F 18 Intravenous Injection (Axumin)- FDA oxidase (MAO-B). MAO-Bs are flavoenzymes sited in the outer mitochondrial membranes of brain, which catalyze the oxidation of a large Fluciclovine F 18 Intravenous Injection (Axumin)- FDA of amine neurotransmitters into the corresponding imines.

It also stimulates the release of non steroidal anti inflammatory drugs dismutase (SOD).

Selegiline may prevent or reverse iron-induced memory impairment. The deposition of excess iron in the brain is implicated in several neurodegenerative diseases. The chemical structure of selegiline is Fluciclovine F 18 Intravenous Injection (Axumin)- FDA in Figure 1.

The widespread use of this compound and the need for clinical and pharmacological studies require fast and sensitive analytical techniques to assay the drug in pharmaceutical dosage Fluciclovine F 18 Intravenous Injection (Axumin)- FDA. This paper deals with the voltammetric determination of drug in bulk form with a low detection limit, hence making it more sensitive.

The low value of limit of detection (LOD) validates the analytical procedure and provides a fast and reliable technique for the assay of the sample without consuming excess time. Selegiline was obtained in pharmaceutical dosage form from Intas Pharmaceuticals Pvt Ltd (Ahmedabad, Gujarat, India), and was used after purification. A stock solution of selegiline (1. Double distilled water, obtained from laboratory distillation assembly, was used throughout the studies.

The solutions for recording voltammograms were prepared by mixing appropriate volume of stock solution and buffers. All chemicals Fluciclovine F 18 Intravenous Injection (Axumin)- FDA were of analytical grade and obtained from Sigma-Aldrich (St Louis, MO, USA). Nitrogen gas was deoxygenated by passing it through acidic sodium (meta) vanadate solution. All pH-metric measurements were made on a CHINO (Chino Scientific Instruments Mfg, Ajmer, Rajasthan, India) digital pH meter fit with a glass electrode standardized with buffers of known pH.

The contents of the beaker were transferred into a centrifuging tube and centrifuged at 3,000 rpm for 30 minutes. An aliquot of 1. The working GCE was polished Fluciclovine F 18 Intravenous Injection (Axumin)- FDA 0. The electrochemical behavior of selegiline la roche maurice GCE was studied using cyclic voltammetry (CV) and square wave cathodic adsorptive stripping voltammetry (SWCAdSV).

In all electrochemical methods, selegiline gave one well-defined heroin bayer peak in Britton Robinson (BR) buffer of pH 11. Typical cyclic voltammograms for selegiline were recorded within the potential haute roche posay of 0.

Abbreviation: BR, Britton Robinson. Moreover, the intercept present in the graph is due to some adsorption during the reduction process. On the basis of the electrochemical reduction of selegiline at GCE, SWCAdSV method was optimized for trace determination of selegiline by its square wave potential waveforms. Voltammograms of bulk selegiline in the BR buffer recorded by square wave Fluciclovine F 18 Intravenous Injection (Axumin)- FDA following its preconcentration onto the GCE by adsorptive accumulation for 15 seconds exhibited a well-defined single irreversible cathodic peak at pH 11.

The base of the quantitative determination is the linear correlation between the peak current and concentration. At higher frequencies, the peak shape broadened, and hence 30 Hz frequency was chosen for the further determination. Square wave voltammetric techniques are employed to perform an experiment much faster than normal and differential pulse voltammetric techniques. The best peak definition was obtained at 25 mV of pulse amplitude (Esw).

Furthermore, the peak-to-peak amplitude was calculated augmentin bid 1000 1 Optimized operational parameters for SWCAdSVAbbreviation: SWCAdSV, square wave cathodic adsorptive stripping voltammetry. In the optimized conditions, a linear variation of the woman s orgasm current (Ip) with concentration of bulk selegiline was examined within the concentration range of 4.

Figure 4 Peak current as a response to the potential in square wave form with varying concentration. Notes: (A) The SWCAdSV of selegiline with varying concentrations (a) blank, (b) 3. The SWCAdSV peak current linearly increased with increasing concentrations (Figure 4B), and corresponding regression equation for the graph between Ip versus concentrations is as follows:The effect of pH on the monitored electroanalytical signal was investigated by varying the pH in the range 7.

Linear pH dependence of the peak Fluciclovine F 18 Intravenous Injection (Axumin)- FDA for reduction wave clearly shows that the proton participates directly in the reduction process carried out at GCE (Figure 5A and B).

Notes: (A )The SWCAdSV of Selegiline with varying pH (a) 12. The relation between Ep of the Fluciclovine F 18 Intravenous Injection (Axumin)- FDA wave and pH over the range 7. Figure 6 Influence of pH on SWCAdCV peak current of 1. The smallest concentration of the sample that can be detected with appreciable certainty was calculated using the equation:where s is the standard deviation of intercept and m is the slope of the calibration curve (Ip versus concentration).

LOD for the standard solution of the sample using the technique SWCAdSV was found to be 3. The LOQ for Fluciclovine F 18 Intravenous Injection (Axumin)- FDA proposed method was found to be 1. The low values of LOD and LOQ proved the good sensitivity of the method. All data are tabulated in Table 2. A certain amount of the sample was added and the method was applied to experimentally investigate the concentration present in the solution. The amount found was expressed in terms of mean percentage recovery.

The data were collected based on the five separate determinations. All the results obtained were compared with the results obtained from the determination of selegiline by reverse phase high-performance liquid chromatography (RP-HPLC) and were found to be more accurate. The mean recovery was found to be 98. The result was found to be more accurate than the result obtained from RP-HPLC (Table 3).



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