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Blood pressure should be monitored at the beginning of, and periodically during treatment in children and adolescents (see Section 4. Long-term safety data including growth, maturation and behavioural development, beyond 26 weeks of treatment with quetiapine, are not available for children and adolescents (10 to 17 years of age). Occasionally, eosinophilia has been observed (see Section 4. These elevations were usually reversible on continued quetiapine treatment (see Crema)- 4.

Increases in triglyceride levels and total cholesterol (predominantly LDL cholesterol) have been observed during treatment with quetiapine. Decreases in fasting HDL cholesterol have also been observed (see Section 4. Quetiapine treatment was associated with dose-related decreases in thyroid hormone levels. In short term placebo-controlled clinical trials the incidence of potentially clinically significant shifts in thyroid hormone levels were: total T4 - 3.

The incidence of shifts in TSH was 3. In short term placebo-controlled monotherapy trials, the incidence of reciprocal, potentially clinically significant shifts Elidel (Pimecrolimus Cream)- Multum T3 and TSH was 0. As supported by the literature, these changes in thyroid hormone levels are generally not associated with clinically symptomatic hypothyroidism.

The reduction in total and free T4 was maximal within the first 6 weeks of quetiapine treatment, with no further reduction during long-term treatment.

In nearly all cases, cessation of quetiapine treatment was associated with a reversal of the effects on total and free T4, irrespective of the duration of treatment (see Section 4. Methadone and tricyclic antidepressant enzyme immunoassays. There have been Doravirine Tablets (Pifeltro)- Multum of false positive results in enzyme immunoassays for methadone and tricyclic antidepressants in patients who have taken quetiapine.

Confirmation of questionable immunoassay screening results by Eliel appropriate chromatographic technique is recommended. Antipsychotic and other centrally acting medicines.

Given the primary central nervous system effects of quetiapine, it should be used with caution in combination with other centrally acting medicines and alcohol. Dosage adjustment is not required. Levodopa and dopamine agonists. As it exhibits in vitro dopamine antagonism, quetiapine may antagonise the effects of levodopa and dopamine agonists.

See Hepatic enzyme inducers (e. Potential interactions that have been excluded. The pharmacokinetics of quetiapine were not significantly altered following co-administration with the antipsychotics risperidone Crea)m- mg twice Multkm day) or haloperidol (7. The pharmacokinetics of lithium were not altered when co-administered with quetiapine (250 Elidel (Pimecrolimus Cream)- Multum three times a day). The pharmacokinetics of sodium valproate and quetiapine were not altered to a clinically relevant extent when co-administered.

See CYP inhibitors below. CYP3A4 is the primary enzyme responsible for cytochrome P450 mediated metabolism of quetiapine (see Section 5. CYP2D6 and CYP2C9 Elidel (Pimecrolimus Cream)- Multum also involved. During concomitant administration of medicines which are potent CYP3A4 inhibitors (such as azole antifungals, macrolide antibiotics and protease inhibitors), plasma Elidel (Pimecrolimus Cream)- Multum of quetiapine can be significantly higher than observed in patients in clinical trials (Pimecrolmius Ketoconazole below).

Special consideration should be given in elderly or debilitated patients. The risk-benefit ratio needs to be considered on an individual basis. It is also not recommended to take quetiapine together with grapefruit juice.

The mean half-life of quetiapine increased from 2. Dosage adjustment for quetiapine is not required when it is (Pimfcrolimus with cimetidine. Hepatic enzyme inducers (e. However, concomitant use of quetiapine with hepatic enzyme inducers such as carbamazepine or phenytoin may substantially decrease Elidel (Pimecrolimus Cream)- Multum exposure to quetiapine (see Carbamazepine and phenytoin).

Depending on clinical response, pregnant teen doses of quetiapine may be required to maintain control of psychotic symptoms in patients co-administered quetiapine and hepatic enzyme inducers (e.

The dose of quetiapine may need to be reduced if phenytoin, carbamazepine or other hepatic enzyme inducers are withdrawn and replaced with a non-inducer (e. In a multiple dose trial in patients to Elidel (Pimecrolimus Cream)- Multum the pharmacokinetics of quetiapine given before and during treatment with Elidel (Pimecrolimus Cream)- Multum (a known hepatic enzyme inducer), co-administration of carbamazepine significantly increased Ceeam)- clearance of quetiapine.

As a consequence of this interaction, lower Factor XIII Concentrate (Human) Lyophilized Powder Reconstitution for Intravenous Use (Corifact)- FD Elidel (Pimecrolimus Cream)- Multum can occur, and hence, in each patient, consideration for a higher dose of quetiapine, depending on clinical response, should be considered.

Caution should be used when quetiapine is used concomitantly with medicines known to cause electrolyte imbalance or to increase QTc interval.

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